![]() All biochemical variables were measured at the central laboratory. The protocols for sample collection, transportation, analysis, and storage have been established ( Collected blood and urine samples were refrigerated immediately and sent to the central laboratory of KoGES (Seoul Clinical Laboratories, Seoul, Korea) every day. Laboratory data were collected at baseline and every 2 years thereafter using a blood sample drawn after a 12-hr fast and the first voided urine. Demographics and medical history were collected by a trained research coordinator. Data were retrieved from the electronic database with assistance from the Korean Centers for Disease Control. This study is supervised by the National Research Institute of Health, Korean Centers for Disease Control and Prevention. Furthermore, we compared the relative predictive value of serum AG ratio with other inflammatory markers to ascertain the clinical relevance of serum AG ratio in predicting kidney outcomes.ĭata collection and assessment of inflammatory markers Therefore, in the present study, we first investigated the prognostic value of serum AG ratio for CKD development using a large scale, community-based, prospective cohort in Korea. However, to the best of our knowledge, the issue whether serum AG ratio associates with declining kidney function has not been explored before. ![]() This significant association of serum AG ratio with chronic inflammation led us to hypothesize that serum AG ratio is a significant predictor of CKD development. In a study of patients with systemic rheumatic diseases, serum AG ratio was correlated with CRP and erythrocyte sedimentation rate concentrations, suggesting the significant association of serum AG ratio with inflammation. Low serum AG ratios have been observed in patients with rheumatoid arthritis and bronchiectasis, both of which are major chronic inflammatory diseases. Although the mechanism by which serum AG ratio has a significant association with unfavorable clinical outcomes has yet to be fully clarified, chronic inflammation has been regarded as a convincing explanation. Įmerging evidence indicates that serum albumin-to-globulin ratio (AG ratio), calculated by dividing serum albumin by serum globulin (total protein-albumin), is an effective prognostic indicator in chronic diseases. Higher levels of inflammatory markers, including white blood cell (WBC), C-reactive protein (CRP), interleukin-6 (IL-6), and soluble tumor necrosis factor receptor 1 (sTNF-R1), are significantly associated with a greater risk of declining kidney function. To date, various inflammatory markers have been studied to determine their association to CKD development. Apart from established traditional risk factors, chronic inflammation has been known to play a crucial role in the pathophysiology of CKD development. Considering higher risk of cardiovascular complications and premature mortality caused by CKD, identifying the risk factors of CKD development would be useful for clinical practice. ![]() The increasing incidence and prevalence of chronic kidney disease (CKD) had led to its global recognition as a preeminent public health problem. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |